Segmaglutide VS Retatrutide

[shaneo75]

Retatrutide and Ozempic (semaglutide) are different drugs with different chemical compositions. While retatrutide mimics three hormones to support weight loss and blood sugar levels, Ozempic only mimics one. Retatrutide also appears to support more significant weight loss than Ozempic.

What is everybody's thoughts on this!

 

[biglouie]

Both for fat loss and blood sugar but I reckon Retatrutide's next level. It's a triple threat hitting 3 hormones while Ozempic only targets 1. So yeah, Retatrutide's probably gonna give better results for losing fat.

That said it's new, so we don’t know the long-term stuff yet. From wht I've read people already feel a bit off with Ozempic, like nausea and stomach issues and Retatrutide might make that worse with the extra hormones it messes with.

So more fat loss... but with possible more side effects

 

[BigAPE]

I have a friend who's been on Ozempic and he's mentioned the above about feeling pretty nauseous and having some stomach issues. I know that it's really helped with his blood sugar and he's lost some decent weight.

Has anyone here tried Retatrutide? I'm wondering if it works better or if the sides are tougher to handle.

 

[shaneo75]

I have a friend who's been on Ozempic and he's mentioned the above about feeling pretty nauseous and having some stomach issues. I know that it's really helped with his blood sugar and he's lost some decent weight.

Has anyone here tried Retatrutide? I'm wondering if it works better or if the sides are tougher to handle.

Am on it now, no side effects thus far

 

[shaneo75]

Retatrutide is a triple agonist that works by binding to and activating three peptide hormone receptors: glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon (GCG):
GLP-1: Regulates appetite and caloric intake by slowing gastric emptying
GIP: Stimulates satiety in the hypothalamus
GCG: Increases energy expenditure and lipolysis, while decreasing lipogenesis
Retatrutide's mechanism of action includes:
Insulin secretion
Retatrutide enhances insulin secretion by binding to GLP-1 and GIP receptors
Glucose homeostasis
Retatrutide improves glucose homeostasis by binding to GLP-1 and GIP receptors
Appetite modulation
Retatrutide refines appetite modulation by binding to GLP-1 and GIP receptors
Energy expenditure
Retatrutide increases energy expenditure by binding to GCG receptors
Fat breakdown
Retatrutide promotes fat breakdown by enhancing energy expenditure with GLP-1 and GIP
Clinical trials have shown that retatrutide can: Reduce body weight, Improve glycemic control, Mitigate cardiovascular risk factors, and Address metabolic dysfunction-associated steatotic liver disease.
The most common adverse events associated with retatrutide are gastrointestinal, and they are usually mild to moderate in severity.

 

[flexymcflexface]

Retatrutide by far the best out of the 2. Tried Semi ages ago and lost next to fuk all.

Retatrutide lost 10kg in a month. Some muscle.

For anyone thinking of doing it here are some tips.

Lift weights (we all should be) i did a dexa scan before and after 30% of my weight loss was muscle i didn't train much for weight and did more cardio. Wasn't the right thing to do.

Eat lots and lots of protein. Keep the protein up to help with keeping muscle.

Drink lots of water and take psyllium husk. As mentioned it slows down the digestive track. You want to make sure your doing consistent poops and not getting bloating in thr belly from not shitting.

 

[doc]

I’ve seen Less long term information/ advertising and trials on Retra but it seems more effective. At the moment it seems better all round - great results with less risk for healthy people. It would be my choice if I wanted to lose weight and control carb cravings

 

[AhhYep]

Both for fat loss and blood sugar but I reckon Retatrutide's next level. It's a triple threat hitting 3 hormones while Ozempic only targets 1. So yeah, Retatrutide's probably gonna give better results for losing fat.

That said it's new, so we don’t know the long-term stuff yet. From wht I've read people already feel a bit off with Ozempic, like nausea and stomach issues and Retatrutide might make that worse with the extra hormones it messes with.

So more fat loss... but with possible more side effects

The nausea usually occurs when upping your dose to quickly. Keep some maxolon on hand incase it gives you nausea.

Delayed stomach emptying usually occurs for the same reason.

Stick to 1mg per week as the max dose.

Have only used Ozempic can’t comment on the other new one

 

[hunterT]

The nausea usually occurs when upping your dose to quickly. Keep some maxolon on hand incase it gives you nausea.

Delayed stomach emptying usually occurs for the same reason.

Stick to 1mg per week as the max dose.

Have only used Ozempic can’t comment on the other new one

Were you satisfied with the results you got from using Ozempic, and was it prescribed by your doctor?

 

[Fredqld]

I was considering it, but I saw a friend's wife age at least ten years within months.

 

[flexymcflexface]

I was considering it, but I saw a friend's wife age at least ten years within months.

That's because they didn't do what it takes to take care of themselves. We see it mostly with femals.

You need to be eating good clean foods still.
Lots of water to help the digestive track seeing it slows it.
Super important this part. They need to be doing weights and lots of it.
Need to preserve muscle. This is the bighest issue woth these drugs is people just let the drug do all the work and iv seen 50% loss of fat but also 50% loss of muscle on scans for people. Losing muscle so fast will 100% make you look older faster.

 

[doc]

That's because they didn't do what it takes to take care of themselves. We see it mostly with femals.

You need to be eating good clean foods still.
Lots of water to help the digestive track seeing it slows it.
Super important this part. They need to be doing weights and lots of it.
Need to preserve muscle. This is the bighest issue woth these drugs is people just let the drug do all the work and iv seen 50% loss of fat but also 50% loss of muscle on scans for people. Losing muscle so fast will 100% make you look older faster.

I was considering it, but I saw a friend's wife age at least ten years within months.

I was considering it, but I saw a friend's wife age at least ten years within months.

That’s scary & possibly mis-use. Losing fat should improve biological aging and increase longevity unless you’re an Eskimo. Using meds to do this doesn’t mean that you ignore nutrition ,exercise and healthy lifestyle habits. These meds are helpful for people with metabolic imbalances that have difficulty getting bf to a healthy level (probably closer to 20% for general public ). Hopefully most of us don’t need them & know how to diet safely if using them temporarily. Side effects of muscle loss will probably limit most of us to a sensible protocol

 

[Fredqld]

That's because they didn't do what it takes to take care of themselves. We see it mostly with femals.


Super important this part. They need to be doing weights and lots of it.
Need to preserve muscle.

The Face is where the aging is really visible; something weird is happening to the facial muscles that goes far beyond what you would expect from a normal diet. Going to the gym would to FA for that aging effect. And you know what? She has stopped, regained quite a bit of weight, and still looks aged. A fail.

 

[flexymcflexface]

The Face is where the aging is really visible; something weird is happening to the facial muscles that goes far beyond what you would expect from a normal diet. Going to the gym would to FA for that aging effect. And you know what? She has stopped, regained quite a bit of weight, and still looks aged. A fail.

Yep they call it the Hollywood face (or something of the likes) muscles in the face deteriorate.

The lady went to far and didn't do it right its well documented why this happens.

My above information helps preventing this issue.

 

[Fredqld]

My above information helps preventing this issue.

I frankly doubt anything can prevent it, this stuff looks like aging in a bottle

 

[doc]

The Face is where the aging is really visible; something weird is happening to the facial muscles that goes far beyond what you would expect from a normal diet. Going to the gym would to FA for that aging effect. And you know what? She has stopped, regained quite a bit of weight, and still looks aged. A fail.

That’s just fat loss around the face- loose skin will always look old & many overweight people look particularly emaciated around the face as they lose weight. That’s why people use fat injections & other fillers for cosmetic purposes. You can’t fail a medication for doing what it’s designed to do

 

[Fredqld]

That’s just fat loss around the face- l

I don't think that's the case; she has gained quite a bit of weight, and the aging in her face has not improved a bit. It appears that 50% of the weight loss from Ozempic (she was on another brand, stronger/newer) might be muscle (possibly heart one too).

 

[Fredqld]

That’s just fat loss around the face

Along with muscle loss, these drugs appear to cause significant loss of elastin and collagen.

 

[doc]

Along with muscle loss, these drugs appear to cause significant loss of elastin and collagen.

Definitely - They are catabolic, you lose everything

 

[EvilRidge]

Lost 18kgs in 4 weeks on Reta it’s magic how it takes it off the stomach
I am 54yrs Old and love the Stuff