Steroid Comparison

ChasetheCase

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AGW Logger
I've been researching the different compounds over the last few weeks and thought some of you may benefit from it. I'm by all means not an expect so please comment if anything should be added or removed, or any other critique and I can update.

SteroidAnabolic:Androgenic RatioMuscle BuildingLVH RiskBP ImpactCardiac IssuesLipids EffectHCT IncreaseOther Side Effects
Testosterone Enanthate100:100★★★★★ModerateModerateModerateNegativeHighAromatization, Water Retention
Testosterone Propionate100:100★★★★★ModerateModerateModerateNegativeHighAromatization, Injection Frequency
Testosterone Cypionate100:100★★★★★ModerateModerateModerateNegativeHighAromatization, Water Retention
Nandrolone Phenylpropionate (NPP)125:37★★★★☆ModerateLowLowNegativeHighProlactin Issues, Water Retention
Deca Durabolin (Nandrolone Decanoate)125:37★★★★☆ModerateLowLowNegativeHighProlactin Issues, Joint Relief
Boldenone (Equipoise)100:50★★★★☆ModerateModerateModerateNegativeVery HighExtreme HCT Increase
Masteron Propionate62:25★★☆☆☆LowLowLowNegativeLowAnti-Estrogenic, Hardening Effect
Masteron Enanthate62:25★★☆☆☆LowLowLowNegativeLowAnti-Estrogenic, Hardening Effect
Trenbolone Acetate500:500★★★★★+Very HighHighExtremeVery NegativeHighAggression, Night Sweats, Prolactin Issues
Trenbolone Enanthate500:500★★★★★+Very HighHighExtremeVery NegativeHighAggression, Night Sweats, Prolactin Issues
Winstrol (Stanozolol)320:30★★★☆☆HighModerateHighVery NegativeLowDry Joints, Liver Toxicity
Sustanon 250100:100★★★★★ModerateModerateModerateNegativeHighAromatization, Long Release
Dianabol (Methandrostenolone)210:60★★★★★HighHighHighVery NegativeModerateExtreme Water Retention, Liver Toxicity
Anavar (Oxandrolone)322-630:24★★★☆☆LowLowModerateNegativeLowMild, Expensive, Hardening Effect
Stanozolol (Winstrol)320:30★★★☆☆HighModerateHighVery NegativeLowDry Joints, Liver Toxicity
Turinabol (Tbol)54:6★★★☆☆LowLowLowNegativeLowMild, Slow Gains, No Water Retention
Anadrol (Oxymetholone)320:45★★★★★+Very HighVery HighExtremeVery NegativeHighExtreme Water Retention, Liver Toxicity
Primobolan (Methenolone)88:44★★★☆☆MildMildMildNeutralNeutralOne of the safest steroids; low suppression


Explanation of Ratings:

  • Anabolic:Androgenic Ratio → Higher means more muscle-building (anabolic) and/or more androgenic side effects.
  • Muscle Building → Rated from ★☆☆☆☆ to ★★★★★+ based on effectiveness for hypertrophy.
  • LVH Risk (Left Ventricular Hypertrophy) → How much the steroid impacts heart muscle thickening.
  • BP Impact (Blood Pressure) → Higher means more risk of hypertension and LVH.
  • Cardiac Issues → How much it negatively affects heart health.
  • Lipids Effect → Negative means it reduces HDL (good cholesterol) and increases LDL (bad cholesterol).
  • HCT Increase (Hematocrit) → Higher means more red blood cell production, increasing blood thickness.
  • Other Side Effects → Includes estrogenic, androgenic, or unique issues.
 
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Pharmacokinetic Parameters for Inclusion​

Half-Life Data​

CompoundHalf-LifeRoute-Specific Considerations
Testosterone Enanthate4-5 daysRequires intramuscular injection
Testosterone Propionate2-3 daysRequires more frequent injections than enanthate ester
Testosterone Cypionate5-8 daysSimilar to enanthate but with slightly longer duration
Nandrolone Phenylpropionate2-3 daysShorter than decanoate ester
Deca Durabolin (Nandrolone Decanoate)6-12 daysLongest half-life among nandrolone esters
Boldenone (Equipoise)10-14 daysProlonged detection window
Masteron Propionate2-3 daysRequires frequent administration
Masteron Enanthate4-5 daysLess frequent administration than propionate
Trenbolone Acetate1-2 daysNecessitates daily or alternate-day administration
Trenbolone Enanthate5-7 daysWeekly administration possible
Winstrol (Stanozolol)8-24 hours (oral) / 1-2 days (injectable)Dual administration routes with distinct kinetics
Sustanon 250Biphasic: 1-3 days (propionate) and 15-18 days (decanoate)Blend designed for sustained release
Dianabol (Methandrostenolone)3-6 hoursRequires multiple daily dosing
Anavar (Oxandrolone)9-10 hoursTypically administered twice daily
Turinabol (Tbol)16-24 hoursOnce daily administration possible
Anadrol (Oxymetholone)8-10 hoursShort half-life despite powerful effects

Oral Bioavailability and First-Pass Metabolism​

CompoundOral BioavailabilityFirst-Pass Hepatic Considerations17α-Alkylation Status
Testosterone (unmodified)<5%Extensive first-pass inactivationNo
Dianabol (Methandrostenolone)30-50%17α-alkylated to resist first-pass metabolismYes
Winstrol (Stanozolol)50-60%17α-alkylated; significant hepatic strainYes
Anavar (Oxandrolone)~97%17α-alkylated but less hepatotoxic than other oralsYes
Turinabol (Tbol)40-60%17α-alkylated with moderate hepatotoxicityYes
Anadrol (Oxymetholone)~50%Highly 17α-alkylated with pronounced hepatotoxicityYes
Note: Injectable compounds bypass significant first-pass metabolism but may still exert hepatotoxic effects via systemic circulation, particularly 17α-alkylated derivatives.

Clinical Monitoring Parameters​

Recommended Monitoring Schedule for Healthcare Professionals​

ParameterBaselineDuring AdministrationPost-CycleClinical Significance
Complete Blood CountEvery 4-6 weeks4-6 weeks after discontinuationMonitors polycythemia risk, particularly with testosterone derivatives
Comprehensive Metabolic PanelEvery 2-4 weeks for orals; Every 4-6 weeks for injectables4-6 weeks after discontinuationAssesses hepatic function (AST, ALT, bilirubin) and renal function
Lipid ProfileEvery 4-8 weeks8-12 weeks after discontinuationMonitors cardiovascular risk via HDL suppression and LDL elevation
Blood PressureWeekly for first month; biweekly thereafterBiweekly until normalizedHypertension is a common early adverse effect
EchocardiographyEvery 6 months for long-term use6 months after discontinuation for high-risk compoundsEvaluates left ventricular hypertrophy and cardiac function
Hormone PanelMid-cycle4-8 weeks after discontinuationTracks endogenous hormone suppression and recovery
PSA (males >40)Every 3-6 months3 months after discontinuationMonitors prostatic effects in at-risk populations
Thyroid FunctionEvery 2-3 months2 months after discontinuationSome AAS affect thyroid hormone binding globulin

Compound-Specific Monitoring Considerations​

CompoundSpecial Monitoring ParametersFrequencyRationale
17α-alkylated orals (Dianabol, Winstrol, Anavar, Anadrol)GGT, ALP, and liver ultrasoundEvery 2-4 weeks during administrationHigher risk of cholestatic liver injury
Trenbolone compoundsPulmonary function, neuropsychiatric assessmentBaseline and as clinically indicatedAssociated with dyspnea and neurocognitive effects
Nandrolone derivativesProlactin levelsBaseline and every 4 weeksExhibits moderate dopaminergic antagonist properties
Testosterone estersEstradiol, DHTEvery 4-6 weeksIdentifies aromatization and 5α-reduction magnitude
All compoundsFasting glucose, HbA1c, HOMA-IRBaseline and every 3 monthsAAS impair insulin sensitivity despite anabolic effects

 
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