HGH and T4
- Thread starter nukes
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When taking growth hormone (GH) to enhance fat-burning, it's recommended to add T4 at a low to moderate dose to maintain the protocol. This will boost fat-burning and prevent a decrease in the effects of GH. It's important to get blood tests often during treatment to determine levels of T4 and T3. Always provide GH with what it needs to function fully, including food.
There's no real protocol per se, if your running 2ius, or 6ius or even 10ius the standard recommendation would be a mild intake of T4, say 50-75mcg. Provide your body with T4 so if and when it needs to convert it will, this way you have both T4 & T3, in lieu of just cutting a corner and taking T3.
supedup
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I wonder? When I take your protocol 100x3/day of mod and ghrp I get so lethargic can hardly function.
Is your ghrp6
I would suggest taking out the mod and see how you feel..are you sure you have the correct reconstitution measurements with the peps, and a good understanding about the tics on a slin? could be taking to much..chances are its the mod!
supedup
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Yeah think I've got it; 1mg peptide + 1ml bac water; 100mcg= #1 on u100 slin pin. Got ipam, hex, g2, g6. I usually rotate em; ipam seems to give the least sides. I'm good with 50/50 mcg of ghrp and mod, go up to 100 I get nausea, lethargy and achy joints.
Never run hgh before, have some coming, gonna start at 2iu; 1 in am, 1 pm and see how that treats me then maybe increase. Have both t3 and t4, been taking 25mcg levothyroxine for bout 3yrs as well as trt
rippedmasterflex
Registered
I've done it with T4, and without t4, you only need to supplement if your bloods say so. Its dependent on the person and also the dose, on 5ius I ran bloods and my t4 was a litle low and my t3 was a little high but nothing was out of range, but on 10ius my t3 was sky high and my t4 was very low, so thats when i added in 100mcg of t4. I don't really believe that if you haven't been using t4, you're wasting half your money. This is all from personal experence but ive had exceptional results with 4-6ius ed with no t4, everything you could hope for from gh. But when the dose gets high you basically need t4 and you need insulin due to the insulin resistance its going to cause. So keep the doses moderate, and you won't need either of those drugs.
powerlifterbro
Registered
Gh raises free t3 and lowers free t4...this causes the reduction in the release of the D1 and D2 enzyme.and increases the D3 enzyme.the D3 enzyme inhibits the anabolic effects of GH on muscle.
Regardless of the amount of gh used any reduction of free t4 and rise in free t3 causes the release of the D3 enzyme...which is counter productive to some degree based on the amount of gh used.
It's actually a very complex process. They include changes in a lot of levels in the pituitary...hypothalamus, and igfs effects on muscle.
In the end no matter what amount of gh used a appropriate t4 dose will increase its Anabolic effects and a dose of t3 will lower those effects.
Regardless of the amount of gh used any reduction of free t4 and rise in free t3 causes the release of the D3 enzyme...which is counter productive to some degree based on the amount of gh used.
It's actually a very complex process. They include changes in a lot of levels in the pituitary...hypothalamus, and igfs effects on muscle.
In the end no matter what amount of gh used a appropriate t4 dose will increase its Anabolic effects and a dose of t3 will lower those effects.
Solid feedback
supedup
Registered
I'm confused by this last statement. My understanding is synthetic exogenous T4(synthroid) converts to T3 once ingested, they both are prescribed for hypothyroidism and have the same net effect but T3 is not often prescribed because it's considered too strong with a high peak saturation since it doesn't have to convert, which cause unstable levels. T4 is used more because it has a longer more stable effect while the body will slowly convert it to T3. So how will T4 increase the anabolic effect of gh but T3 lower it??
Thanks for the info guys.
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powerlifterbro
Registered
Apologies for the essay bro. Your statement is accurate unless exogenous GH is used. GH increases the conversion of T4 into T3. The conversion process of T4 to T3 by the D1 and D2 enzymes is critical for GH to exert its anabolic and nitrogen-retaining effects on muscle, which won't occur if T3 levels are highly elevated due to its effects on the negative feedback loop sending a signal to the thyroid axis to cease the release of the D1, D2 enzyme and release the D3 enzyme. The D3 enzyme halts the conversion process of T4 and T3.
In the past, exogenous T3 was considered by some to be the answer to GH use since they are both synergistic and are, but that is with the D1, D2 enzyme. The issue is with exogenous GH use, those enzymes are inhibited, and the inhibitor is the D3 enzyme.
It all comes down to those 2 enzymes needed for conversion as the conversion process is what increases the anabolic effects of GH. There was a study done on people with lacking natural growth hormone, and it was clear GH needed elevated T3 levels to exert its effects but through study all this was done with the use of T4 to create more conversion. You can't continue to maintain high T3 levels with low T4 levels cause the body won't allow it via the D3 enzyme.
When I first started studying this a few years back, it was confusing, and there are a lot more in-depth reasons like GnRH, IGF, GH, and a lot of receptor effects, etc. It's not an easy study to grasp, but I will say in real-world experience, I see GH + T4 have more profound effects on muscle than no T4 or GH + T3.
Hmmm, I’ve been feeling very tired throughout the day . I take my gh in the morning .
Is this because of not supplementing t4 ?
Is this because of not supplementing t4 ?
slamid
Registered
It could be. GH does mess with your thyroid and it also lowers your T4 levels... as a result makes you feel sluggish. Just try adding some T4 to your routine and see if it helps. You can add it to your morning routine with the GH in the morning. A good starting point would proabbly be aroound 50mcg then work your way up to 100 and see how you feel.
